DNA damage & the DNA damage response (DDR)
The DDR is required for cell survival. Several repair pathways cooperate and sometimes compete in response to different types of DNA damage, leading to the effective maintenance of genomic material in cells.
The concept of synthetic lethality was first derived from genetic studies in model organisms, where mutation of a particular gene becomes lethal only through mutation or loss of another gene.
Ubiquitin processes in DDR
A wealth of scientific evidence shows that the post translational modification process of ubiquitylation and its reversal by deubiquitylation play key roles in regulating the DDR and associated processes.
Nov 18, 2013
Pfizer Venture Investments join MISSION investor syndicate to to drive development of ubiquitin pathway inhibitors and advance compounds through preclinical development for genetically-defined cancers