DNA damage & the DNA damage response (DDR)
The DDR is required for cell survival. Several repair pathways cooperate and sometimes compete in response to different types of DNA damage, leading to the effective maintenance of genomic material in cells.
The concept of synthetic lethality was first derived from genetic studies in model organisms, where mutation of a particular gene becomes lethal only through mutation or loss of another gene.
Ubiquitin processes in DDR
A wealth of scientific evidence shows that the post translational modification process of ubiquitylation and its reversal by deubiquitylation play key roles in regulating the DDR and associated processes.
Jan 09, 2015
Appointment strengthens UK drug discovery team for transformational change.
Cambridge, UK - 9 January 2015 – MISSION Therapeutics, a company focused on the discovery and development of modulators of the deubiquitylating (DUB) enzyme family for the treatment of cancer and other diseases, announces the appointment of Dr Anker Lundemose MD PhD as Chief Executive Officer.