Recruitment

We are currently recruiting for a Medicinal Chemist, an Head of Bioinformatics and a Screening Scientist, please see adverts below

Head of Bioinformatics (permanent) 

MISSION is looking for an enthusiastic Head of Bioinformatics to join our drug discovery team on a permanent basis. You will be involved in shaping MISSION’s progression towards clinical candidate selection and development. As a member of the Biology team you will be focusing on delivering target validation support, biomarkers and clinical line of sight for our most advanced projects. Your role will be to build and support all bioinformatics activities, either internally or externally. You will take a lead in defining the strategies that MISSION will use to develop its platform of deubiquitylating enzyme projects. Specifically, you will provide computational science and bioinformatics expertise to the project teams during the discovery and development phases of small molecule drug discovery programs including their translational stages.

Duties and responsibilities

Contribute to the identification and validation of novel cancer targets leveraging public and proprietary cancer genomics, genetics data and working closely with the target validation team.

  • Represent bioinformatics discipline as part of the drug discovery project teams by  providing a broad range of support to ensure best use of all relevant data impacting project decisions for target validation, disease linkage, biomarker identification and resistance mechanisms:
  • Proactively identify opportunities and propose informatics solutions
  • Independently carry out informatics analysis
  • Summarize and present scientific results with clear conclusions and recommendations.
  • Contribute to the development of innovative data management/integration and information intelligence solutions:
  • Act as a bridge between end users and developers to clarify and define system requirements
  • Provide bioinformatics support to ensure data quality and usability
  • Conduct data mining to extract maximal value out of information system
  • Maintain expertise in state-of-the-art bioinformatics methods
  • Communication:
  • Proactively communicate activities and status to your supervisor and key stakeholders
  • Generate technical documents, external publications and presentations
  • Must be able to multi-task
  •  

Qualifications and Experience

Ph.D. in bioinformatics, computational biology, computer science, or related field with significant relevant working experience.

  • Oncology expertise.
  • Expertise in data analysis including:
  • Next generation sequencing data
  • Diverse types of ‘omics’ data, such as gene expression profiling, copy number profiling, RNAi screening, expert user of genomics data analysis tools/packages, proteomic studies
  • Solid understanding of statistical analysis principles and expert user of one of the statistical data analysis tools/packages, such as R, matlab, or equivalent
  • Ability to independently manipulate large datasets
  • Proficiency in common bioinformatics databases and tools, can independently design and perform diverse bioinformatics tasks
  • Excellent computer skills including database and software development training/experience.
  • Ability to solve problems and troubleshoot
  • Must be a team player. Excellent interpersonal skills with a proven record of interacting with biologists effectively
  • Excellent written and verbal communication skills
  • Proven track record of identification and interaction with CROs, academic groups and clinicians  

Benefits

We are located in new labs on the Babraham campus; we offer a competitive salary, along with a contributory pension scheme plus other excellent benefits.

This is an exceptional opportunity to join a fast growing biotech company that is at a decisive stage in its development.  If you would like to apply for this position, please send your CV with a covering letter to hr@missiontherapeutics.com

Please note that applicants must have proof of the right to work in the UK.    

No agencies, thank you

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Cell Biology - Screening Scientist  (12 month Fixed Term Contract)

MISSION is looking for an enthusiastic and experienced screening scientist to join our Cambridge, UK based facilities on the Babraham Research Campus, at the heart of Europe’s largest biotechnology cluster for a 12 month Fixed Term contract.

The applicant will have previous laboratory experience and be educated to BSc, MSc or equivalent in a life science subject. Ideally you will have hands-on experience with a broad range of scientific techniques along with an understanding of oncology. The successful candidate will be involved in the day to day running of in vitro and cell based screening assays to support the company’s small molecule drug discovery process. This will include plate based screening assays, protein production and assay development as well as use of databases to capture and analyse data.  Laboratory work is a major component of this role and a level of independence in experimental design and data analysis is required.

Essential skills

  • Life science B.Sc. or equivalent experience
  • Previous laboratory experience
  • Methodical with excellent attention to detail
  • Team player with good communication skills
  • Ability to work independently under minimal supervision

Desirable skills

  • Experience in running in vitro screening assays
  • Knowledge of recombinant protein production and purification
  • Practical experience of assay development and troubleshooting
  • Proficient in tissue culture techniques
  • Strong computer/software skills for data entry/analysis

Benefits

We are located in new labs on the Babraham Camous; we offer a competitive salary, along with a contributory pension scheme plus other excellent benefits.

This is an exceptional opportunity to join a fast growing biotech company that is at a decisive stage in its development. If you would like to apply for this position, please send your CV with a covering letter to hr@missiontherapeutics.com

Please note that applicants must have proof of the right to work in the UK.    The closing date for applications is 3rd November  

No agencies, thank you

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Medicinal Chemist  (permanent)

MISSION is looking for an experienced Medicinal Chemist, with a passion for drug discovery, to join on a permanent basis at its Cambridge UK based facilities on the Babraham Research Campus, at the heart of Europe’s largest biotechnology cluster.

The applicant will have extensive experience of designing and progressing small molecule drug candidates. The role requires working within a small project management team, utilising external CROs for synthetic chemistry, with responsibility for providing the medicinal chemistry input for a project.

Essential Skills

A proven track record of drug candidate delivery. Extensive experience as a design lead with supervision of a dedicated synthetic team. Experience of utilising structure based drug design principles to optimise drug-like properties. A thorough knowledge of modern synthetic methodology and medicinal chemistry concepts. A good eye for detail and the ability to spot SAR trends within complex data sets.  A good knowledge of pharmacology, IP strategy, human pharmacokinetic prediction and candidate selection criteria. A reasonable proficiency at using molecular modelling software.  The ability to work independently to challenging timelines, and to communicate/influence effectively within an interdisciplinary team. Lead-to-candidate project management experience would be highly desirable.

 Benefits

We are located in new labs on the Babraham campus. We offer a competitive salary, along with a contributory pension scheme plus other excellent benefits.

This is an exceptional opportunity to join a fast growing biotechnology company at an exciting stage in its development. If you would like to apply for this position, please send your CV and covering letter to hr@missiontherapeutics.com   

Please note applicants must have proof of the right to work in the UK.  The closing date for applications is 10th November     No agencies, thank you